We aimed to identify the white matter structures of fatigue in

He and his new bride are happy to chat. When we compliment him on his shirt, he smiles. “I got it in Vegas,” he informs us, running a hand through his gel laden hair. Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI).

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